Leptina

LEP
	Proteinak kodetzen dituen genea
Identifikadoreak
	Homologene: 193 Genenames: LEP Ensemble: ENSG00000174697
Taxoia	Homo sapiens
Kokapena
Kromosoma	human chromosome 7 (en)
Kokapen zitogenetikoa	7q32.1
Hasiera	127881337 bp
Amaiera	127897681 bp
Transkripzioak
RNA ID	XM_005250340 eta NM_000230
Ensembl	ENST00000308868
Sagu arrunt	Lep (en)
Arratoi arrunt	Lep (en)
Gene-adierazpen eredua
Ontologia
Kodetzen du	Leptina
Funtzio-molekularrak	Ikusi hormone activity (en) ; peptide hormone receptor binding (en) ; signaling receptor binding (en) ;
Osagai-zelularra	Ikusi zitoplasma; zelulaz kanpoko eremu; extracellular space (en) ;
Prozesu-biologikoak	Ikusi regulation of protein phosphorylation (en) ; response to dietary excess (en) ; cellular response to retinoic acid (en) ; positive regulation of developmental growth (en) ; negative regulation of glucagon secretion (en) ; placenta development (en) ; cardiac muscle hypertrophy (en) ; regulation of angiogenesis (en) ; prostaglandin secretion (en) ; regulation of intestinal cholesterol absorption (en) ; T cell differentiation (en) ; positive regulation of reactive oxygen species metabolic process (en) ; central nervous system neuron development (en) ; Erritmo zirkadiano; positive regulation of ion transport (en) ; angiogenesis (en) ; glucose metabolic process (en) ; positive regulation of peroxisome proliferator activated receptor signaling pathway (en) ; positive regulation of hepatic stellate cell activation (en) ; regulation of endothelial cell proliferation (en) ; intestinal absorption (en) ; response to ethanol (en) ; negative regulation of autophagy (en) ; positive regulation of p38MAPK cascade (en) ; Kinasa B proteinaren komunikazio erregulatzaile positibo; negative regulation of metabolic process (en) ; negative regulation of vasoconstriction (en) ; glucose homeostasis (en) ; regulation of insulin secretion (en) ; regulation of steroid biosynthetic process (en) ; insulin secretion (en) ; regulation of natural killer cell activation (en) ; regulation of fat cell differentiation (en) ; response to vitamin E (en) ; response to nutrient levels (en) ; bone mineralization involved in bone maturation (en) ; positive regulation of T cell proliferation (en) ; positive regulation of protein import into nucleus (en) ; regulation of brown fat cell differentiation (en) ; fatty acid beta-oxidation (en) ; regulation of metabolic process (en) ; hormone metabolic process (en) ; positive regulation of MAPK cascade (en) ; positive regulation of TOR signaling (en) ; cellular response to L-ascorbic acid (en) ; ovulation from ovarian follicle (en) ; activation of protein kinase C activity (en) ; ugalketa sexual; negative regulation of cartilage development (en) ; response to nutrient (en) ; negative regulation of glutamine transport (en) ; leptin-mediated signaling pathway (en) ; bile acid metabolic process (en) ; female pregnancy (en) ; negative regulation of apoptotic process (en) ; cholesterol metabolic process (en) ; positive regulation of follicle-stimulating hormone secretion (en) ; negative regulation of transcription by RNA polymerase II (en) ; negative regulation of appetite (en) ; regulation of protein localization to nucleus (en) ; regulation of blood pressure (en) ; negative regulation of glucose import (en) ; leukocyte tethering or rolling (en) ; negative regulation of lipid storage (en) ; adipose tissue development (en) ; positive regulation of insulin receptor signaling pathway (en) ; bone growth (en) ; positive regulation of receptor signaling pathway via JAK-STAT (en) ; glycerol biosynthetic process (en) ; positive regulation of luteinizing hormone secretion (en) ; fatty acid catabolic process (en) ; regulation of gluconeogenesis (en) ; response to estradiol (en) ; komunikazio intrazelularraren transdukzio; adult feeding behavior (en) ; response to hypoxia (en) ; regulation of natural killer cell proliferation (en) ; eating behavior (en) ; positive regulation of cytokine production (en) ; regulation of cytokine production involved in inflammatory response (en) ; regulation of nitric-oxide synthase activity (en) ; response to activity (en) ; cellular response to leptin stimulus (en) ; regulation of cell cycle (en) ; regulation of natural killer cell mediated cytotoxicity (en) ; positive regulation of fat cell apoptotic process (en) ; positive regulation of cell population proliferation (en) ; regulation of lipoprotein lipid oxidation (en) ; positive regulation of phosphatidylinositol 3-kinase signaling (en) ; seinale transdukzio; regulation of bone remodeling (en) ; lipid metabolism (en) ; negative regulation of appetite by leptin-mediated signaling pathway (en) ; interleukin-12 production (en) ; positive regulation of tumor necrosis factor production (en) ; interleukin-6 production (en) ; response to insulin (en) ; tyrosine phosphorylation of STAT protein (en) ; Fagozitosi; energy reserve metabolic process (en) ; positive regulation of tyrosine phosphorylation of STAT protein (en) ; regulation of signaling receptor activity (en) ; determination of adult lifespan (en) ; positive regulation of phosphatidylinositol 3-kinase signaling (en) ; positive regulation of TOR signaling (en) ; positive regulation of receptor signaling pathway via JAK-STAT (en) ; regulation of lipid biosynthetic process (en) ; positive regulation of cold-induced thermogenesis (en) ; positive regulation of p38MAPK cascade (en) ; activation of protein kinase C activity (en) ; aorta development (en) ; regulation of catalytic activity (en) ; elastin metabolic process (en) ;

Leptina apetituarekin edo gosearekin zerikusia duen hormona bat da. Berez sortzen du organismoak, eta burmuinetan desaktibatu egiten du gose-irudipena. Jateak ematen duen atsegina ere desagerrarazi egiten du leptinak, garuneko plazer-guneei eragiten baitie (zehazki, murriztu egiten du gune horietako jarduera).

Leptinarik ekoizten ez duten pertsonek edo kopuru erregularretan egiten ez dutenek nekezago kontrolatzen dituzte jangale- eta gose-irudipenak, eta itsumustuan jaten dute; gainera, ez dute joerarik elikagaiak bereizi eta hautatzeko, ez dute beren burua kontrolatzeko gaitasunik, eta pisu gehiegi izan ohi dute.

Leptinaren errezeptorea leptina jasotzen duen proteina espezifikoa da^[3].

ErreferentziakAldatu

↑ GRCh38: Ensembl release 89: ENSG00000174697. Ensembl.
↑ GRCh38: Ensembl release 89: ENSG00000174697. Ensembl.
↑ Tartaglia, Louis A.; Dembski, Marlene; Weng, Xun; Deng, Nanhua; Culpepper, Janice; Devos, Rene; Richards, Grayson J.; Campfield, L.Arthur et al.. (1995-12). «Identification and expression cloning of a leptin receptor, OB-R» Cell 83 (7): 1263–1271. doi:10.1016/0092-8674(95)90151-5. ISSN 0092-8674. (Noiz kontsultatua: 2021-06-03).

Kanpo estekakAldatu

Datuak: Q223739
Multimedia: Leptin (obesity protein)

[1] GRCh38: Ensembl release 89: ENSG00000174697. Ensembl.

[2] GRCh38: Ensembl release 89: ENSG00000174697. Ensembl.

[3] Tartaglia, Louis A.; Dembski, Marlene; Weng, Xun; Deng, Nanhua; Culpepper, Janice; Devos, Rene; Richards, Grayson J.; Campfield, L.Arthur et al.. (1995-12). «Identification and expression cloning of a leptin receptor, OB-R» Cell 83 (7): 1263–1271. doi:10.1016/0092-8674(95)90151-5. ISSN 0092-8674. (Noiz kontsultatua: 2021-06-03).

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