Nerbio hazkunde-faktore

NGF
Egitura erabilgarria
PDB	Ortologoaren bilaketa: PDBe RCSB
PDB ID kodeen zerrenda
	4ZBN, 1SG1, 1WWW, 2IFG, 4EDW, 4EDX
Identifikatzaileak
Aliasak	NGF (HUGO), Beta-HSAN5, NGFB, nerve growth factor
Kanpoko IDak	OMIM: 162030 MGI: 97321 HomoloGene: 1876 GeneCards: NGF OMA: NGF - orthologs
Genearen kokapena (gizakia)
	Kromosoma: 1 (gizakia)
Amaiera	115.338.770 bp
Genearen kokapena (sagua)
	Kromosoma: 3 (sagua)
Amaiera	102.428.329 bp
RNA adierazpen eredua
	Adierazpen ohikoena
	cartilage tissue ; ; left uterine tube ; ; right auricle ; ; right ovary ; ; apex of heart ; ; ascending aorta ; ; left ovary ; ; Tibial arteries ; ; Ezkerreko bentrikulu; ; Descending thoracic aorta ;
	Adierazpen ohikoena
	Guruin submaxilar; ; Eskuineko bentrikulu; ; enbrioi; ; genital tubercle ; ; endothelial cell of lymphatic vessel ; ; dentate gyrus of hippocampal formation granule cell ; ; enbrioi; ; skin of lower limb ; ; right kidney ; ; Erdi belarri;
	Erreferentziazko adierazpen datu gehiago
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	peptidase inhibitor activity ; enzyme inhibitor activity ; proteina lotura ; metalloendopeptidase inhibitor activity ; nerve growth factor receptor binding ; growth factor activity ; signaling receptor binding ;
Zelularen osagaia	endosoma ; Golgi lumen ; zelulaz kanpoko eremu ; cytoplasmic vesicle ; extracellular space ; zitosol ; synaptic vesicle ; Axoi ; Dendrita ;
Prozesu biologikoa	negative regulation of neuron apoptotic process ; regulation of neuron differentiation ; neuron projection morphogenesis ; negative regulation of peptidase activity ; neurotrophin TRK receptor signaling pathway ; cell-cell signaling ; negative regulation of apoptotic process ; regulation of cysteine-type endopeptidase activity involved in apoptotic process ; positive regulation of axonogenesis ; positive regulation of gene expression ; positive regulation of apoptotic process ; nerve growth factor processing ; extrinsic apoptotic signaling pathway via death domain receptors ; phosphatidylinositol-mediated signaling ; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ; microtubule-based movement ; activation of cysteine-type endopeptidase activity involved in apoptotic process ; positive regulation of Ras protein signal transduction ; transmembrane receptor protein tyrosine kinase signaling pathway ; peripheral nervous system development ; Oroimen ; negative regulation of cell population proliferation ; regulation of signaling receptor activity ; nerve development ; nerve growth factor signaling pathway ; positive regulation of DNA binding ; positive regulation of neuron differentiation ; positive regulation of collateral sprouting ; modulation of chemical synaptic transmission ;
	Iturburuak: : Amigo / QuickGO
Ortologoak
	4803
	18049
	ENSG00000134259
	ENSMUSG00000027859
	P01138
	P01139
	NM_002506
	NM_001112698; NM_013609
	NP_002497
	NP_001106168; NP_038637
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

Nerbio hazkunde-faktore (NGF) faktore neotrofiko eta neuropeptido bat da, neurona zehatz batzuen hazkuntza, mantenu, hedatze eta biziraupenean parte-hartzen duena. Ziurrenik hazkunde-faktore prototipoa da, eta deskribatu zen lehenetako bat izan zen. Rita Levi-Montalcini eta Stanley Cohenek 1956an isolatu eta Medikuntzako Nobel Saria eskuratu zuten. Garai hartatik hainbat prozesu biologiko aurkitu dira NGFk parte-hartzen duena, horietako bi pankreako beta-zelulen biziraupena eta sistema-immunitarioaren erregulazioa izanik.

Azken urteotako ikerketak aurkitu du NGFren kontzentrazioa odol plasman handiagoa dela harreman erromantiko bat izan dutenen artean 12 hilabete baino gehiagoz, izan ez dutenengan baino^[5].

Erreferentziak

↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134259 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027859 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ EMANUELE, E; POLITI, P; BIANCHI, M; MINORETTI, P; BERTONA, M; GEROLDI, D. «Raised plasma nerve growth factor levels associated with early-stage romantic love» Psychoneuroendocrinology 31 (3): 288–294. doi:10.1016/j.psyneuen.2005.09.002. (Noiz kontsultatua: 2017-10-23).

Kanpo estekak

Datuak: Q417782
Multimedia: Nerve growth factors / Q417782

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134259 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027859 – Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] EMANUELE, E; POLITI, P; BIANCHI, M; MINORETTI, P; BERTONA, M; GEROLDI, D. «Raised plasma nerve growth factor levels associated with early-stage romantic love» Psychoneuroendocrinology 31 (3): 288–294. doi:10.1016/j.psyneuen.2005.09.002. (Noiz kontsultatua: 2017-10-23).

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