Glukagoi

Identifikadoreak
Taxoia	Homo sapiens
Kokapena
Hasiera
Amaiera
	<div style="position: absolute; left: Adierazpen errorea: Ustekabeko * eragileapx; top: 18px; padding: 0;">[[File:Red rectangle Espresio akatsa: Ez dago operadorerik -(r)entzatx18.png\|Espresio akatsa: Ez dago operadorerik -(r)entzatpx\|link=File:Red rectangle 4x18.png\|alt=kokapena\|]][[File:\|285px\|link=File:\|alt=\|]]
Transkripzioak
Gene-adierazpen eredua
Ontologia
Funtzio-molekularrak	Ikusi proteina lotura; identical protein binding (en) ; hormone activity (en) ; glucagon receptor binding (en) ;
Osagai-zelularra	Ikusi zitoplasma; endoplasmic reticulum lumen (en) ; zelulaz kanpoko eremu; secretory granule lumen (en) ; extracellular space (en) ;
Prozesu-biologikoak	Ikusi negative regulation of execution phase of apoptosis (en) ; G proteina errezeptore akoplatuaren komunikazio bidea; regulation of insulin secretion (en) ; cellular response to glucagon stimulus (en) ; positive regulation of peptidyl-serine phosphorylation (en) ; positive regulation of calcium ion import (en) ; positive regulation of histone H3-K4 methylation (en) ; positive regulation of peptidyl-threonine phosphorylation (en) ; feeding behavior (en) ; positive regulation of ERK1 and ERK2 cascade (en) ; positive regulation of protein binding (en) ; cell population proliferation (en) ; seinale transdukzio; positive regulation of protein kinase activity (en) ; adenylate cyclase-modulating G protein-coupled receptor signaling pathway (en) ; protein kinase A signaling (en) ; positive regulation of insulin secretion involved in cellular response to glucose stimulus (en) ; response to starvation (en) ; negative regulation of apoptotic process (en) ; regulation of signaling receptor activity (en) ; adenylate cyclase-activating G protein-coupled receptor signaling pathway (en) ;

Glukagoi 29 aminoazido dituen hormona peptidikoa da, gluzidoen metabolismoan jarduten duena. Bere pisu molekularra 3.485 daltonekoa da, eta 1923an aurkitu zuten Kimball eta Murlin zientzialariek. Pankreako Langerhansen uhartetxoetako alfa zelulek jariatzen dute.

Bere egitura primarioa honako hau da:

NH₂-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-COOH

Glukagoiak intsulinaren aurkako efektua du: odolean dagoen glukosa kopurua igotzen du. Horretarako, gibelean dagoen glukogenoaz jarduten du, glukogeno horren hidrolisia bultzatuz (glukosa sortzeko). Bestalde, glukolisia inhibitzen du (hots, glukosaren oxidazioa).

Organismoak odolean glukosa gehiago behar duenean glukagoiaren sintesia areagotzen du. Adrenalina hormonaren jarduera glukagoiaren antzekoa da, glukosaren kontzentrazioa odolean ere igotzen baitu.

ErreferentziakAldatu

↑ GRCh38: Ensembl release 89:. Ensembl.
↑ GRCh38: Ensembl release 89:. Ensembl.

Kanpo estekakAldatu

Datuak: Q170617
Multimedia: Glucagon

[1] GRCh38: Ensembl release 89:. Ensembl.

[2] GRCh38: Ensembl release 89:. Ensembl.

[1]

[2]

Identifikadoreak
Taxoia	Homo sapiens
Kokapena
Hasiera	^[1]
Amaiera	^[2]
<div style="position: absolute; left: *Adierazpen errorea: Ustekabeko eragileapx; top: 18px; padding: 0;">[[File:Red rectangle Espresio akatsa: Ez dago operadorerik -(r)entzatx18.png\|Espresio akatsa: Ez dago operadorerik -(r)entzat**px\|link=File:Red rectangle 4x18.png\|alt=kokapena\|]] [[File:\|285px\|link=File:\|alt=\|]]
Transkripzioak
Gene-adierazpen eredua

Ontologia
Funtzio-molekularrak	Ikusi proteina lotura identical protein binding ^(en) hormone activity ^(en) glucagon receptor binding ^(en)
Osagai-zelularra	Ikusi zitoplasma endoplasmic reticulum lumen ^(en) zelulaz kanpoko eremu secretory granule lumen ^(en) extracellular space ^(en)
Prozesu-biologikoak	Ikusi negative regulation of execution phase of apoptosis ^(en) G proteina errezeptore akoplatuaren komunikazio bidea regulation of insulin secretion ^(en) cellular response to glucagon stimulus ^(en) positive regulation of peptidyl-serine phosphorylation ^(en) positive regulation of calcium ion import ^(en) positive regulation of histone H3-K4 methylation ^(en) positive regulation of peptidyl-threonine phosphorylation ^(en) feeding behavior ^(en) positive regulation of ERK1 and ERK2 cascade ^(en) positive regulation of protein binding ^(en) cell population proliferation ^(en) seinale transdukzio positive regulation of protein kinase activity ^(en) adenylate cyclase-modulating G protein-coupled receptor signaling pathway ^(en) protein kinase A signaling ^(en) positive regulation of insulin secretion involved in cellular response to glucose stimulus ^(en) response to starvation ^(en) negative regulation of apoptotic process ^(en) regulation of signaling receptor activity ^(en) adenylate cyclase-activating G protein-coupled receptor signaling pathway ^(en)